Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson's Disease

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2017,（5）
• 页码范围: 501-509
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s12264-017-0171-9

摘要

We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson's disease (PD) over a 2-year period.Data were acquired from 23 PD patients at baseline and follow-up,and 27 age-and sex-matched normal controls.Regional homogeneity (ReHo) and voxel-based-morphometry (VBM) were used to identify differences in local spontaneous brain activity and grey matter volume.With disease progression,we observed a progressive decrease in ReHo in the sensorimotor cortex,default-mode network,and left cerebellum,but increased ReHo in the supplementary motor area,bilateral temporal gyms,and hippocampus.Moreover,there was a significant positive correlation between the rates of ReHo change in the left cerebellum and the rates of change in the Unified Parkinson's Disease Rating Scale-Ⅲ scores.VBM revealed no significant differences in the grey matter volume among the three sets of acquisitions.We conclude that ReHo may be a suitable non-invasive marker of progression in PD.