Antiplatelet aggregation activity of some ferrocenylphenylimine compounds

• 作者: Andy R.Opoku Foluso O.Osunsanmi J.Catherine Ngila Monisola I.Ikhile
• 来源期刊: 中国药学（英文版）
• 学科: 医学
• 年，卷（期）: 2017,（6）
• 所属期刊栏目: 简报
• 页码范围: 460-464
• 页数: 5页
• 分类号: R973
• 语种: 英文

摘要

Platelet hyper-aggregability triggered death and disability due to cardiovascular diseases is increasing worldwide and becoming a global concern.Therefore,it is necessary to synthesize newer drugs for the management of platelet aggregation.In this study,we investigated the antiplatelet aggregation activity of a novel series of ferrocenylimine compounds (3-10),N-(3-nitro-2-hydroxylbenzylidene)-3-ferrocenylimine (3),N-(3-bromo-2-hydroxylbenzylidene)-3-ferrocenylimine (4),N-(3-bromo-5-chlorosalicylidene)-3-ferrocenylimine (5),N-(ferrocenylformidene)-3-ferrocenylimine (6),N-(3-nitro-2-hydroxylbenzylidene)-4-ferrocenylimine (7),N-(3-bromo-2-hydroxylbenzylidene)-4-ferrocenylimine (8),N-(3-bromo-5-chlorosalicyl)-4-ferrocenylimine (9),N-(ferrocenylformidene)-4-ferrocenylimine (10) on thrombin-and ADP-induced platelet aggregation.The synthesized ferrocenylimine compounds (3-10)were found to exhibit higher antiplatelet aggregation activity than their precursors,which are 3-ferrocenylaniline (compound 1)and 4-ferrocenylaniline (compound 2).Among the derivatives,compounds 5,6 and 10 possessed excellent platelet aggregationinhibition against the agonists.