Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity

• 来源期刊: 生物医学研究杂志（英文版）
• 学科: 医学
• 年，卷（期）: 2017,（6）
• 页码范围: 503-511
• 页数: 9页
• 分类号: R122.2
• 语种: 英文

摘要

Particulate matters (PM) are one of the major body burdens leading to diseases.We investigated the capacities of a hydrogen-enriched water (HW) eliminating carbon nanoparticles (CNP) and carbon microparticles (CMP) from the lungs and blood,respectively.In CNP-elimination test,rats were orally administered with purified water (PW) or HW (10 or 30 mL/kg/day) for 10 weeks.At the time point of 4 weeks,the rats were challenged with intratracheal instillation of CNP (4 mg).CNP accumulated in the airways and alveoli,and induced inflammatory lesions.Such pneumoconiosis was markedly improved by feeding HW,while PW was ineffective.CNP-induced pneumoconiosis caused systemic hematological alterations,decreasing major inflammatory cells,but markedly increasing eosinophils,indicative of an allergic reaction,which were attenuated by treatment with HW.Such PM-eliminating and antiallergic effects of HW reduced body burden as confirmed from the facilitated recovery of body and lung weights.In CMP-clearance test,mice were orally administered with PW or HW for 7 days,and intravenously injected with CMP (300 mg/kg).CMP was rapidly eliminated from the blood in HW-fed mice.Indeed,the phagocytic indices increased to 3.5 and 6.7 folds at 10 and 30 mL/kg of HW,in comparison with a negligible effect of PW.As a mechanism study,only HW significantly inhibited lipid peroxidation in vitro Fenton reaction-mediated.OH-generating system.Collectively,the results indicate that HW not only effectively eliminated PM from the lungs and blood by enhancing phagocytic activity,but also attenuated the lung injuries by inhibiting lipid peroxidation.