Finding the ‘Guilty’ Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2017,（1）
• 页码范围: 115-117
• 页数: 3页
• 语种: 英文
• DOI: 10.1007/s12264-016-0065-2

摘要

Parkinson's disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide,but its cause and pathogenesis are still not fully understood.Earlier studies have shown that SNCA,which encodes α-synuclein,is one of the key genes associated with PD.Single-nucleotide polymorphism (SNP) variants of SNCA are thought to be correlated with disease onset.The underlying mechanisms however are enigmatic.A recent study published in Nature revealed that one of the SNP variants in the SNCA non-coding element elevated α-synuclein expression in human neurons by reducing the binding efficiency of transcrption factors,demonstrating a previously uncharted role for SNPs in the pathogenesis of PD.