Effect of Integrated Chinese and Western Medicine Therapy on Severe Hand, Foot and Mouth Disease: A Prospective,Randomized, Controlled Trial

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2017,（12）
• 页码范围: 887-892
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11655-016-2504-3

摘要

Objective:To evaluate the efficacy and safety of Chinese medicine (CM) plus Western medicine (WM) in the treatment of pediatric patients with severe hand,foot and mouth disease (HFMD) by conducting a prospective,controlled,and randomized trial.Methods:A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone (224 cases,WM therapy group) or CM [Reduning Injection（热毒宁注射液）or Xiyanping Injection（喜炎平注射液）]plus WM therapy (227 cases,CM plus WM therapy group)for 7-10 days,according to a web-based randomization system.The primary outcome was fever clearance time,which was presented as temperature decreased half-life time.The secondary outcomes included the rate of rash/herpes disappearance within 120 h,as well as the rate for cough,runny nose,lethargy and weakness,agitation or irritability,and vomiting clearance within 120 h.The drug-related adverse events were also recorded.Results:The temperature decreased half-life time was 40.4 h in the WM therapy group,significantly longer than 27.2 h in the CM plus WM therapy group (P＜0.01).Moreover,the rate for rash/herpes disappearance within 120 h was 43.6％ (99/227) in the CM plus WM therapy group,significantly higher than 29.5％ (66/224) in the WM therapy group (P＜0.01).In addition,the rate for cough,lethargy and weakness,agitation or irritability disappearance within 120 h was 32.6％ (74/227) in the CM plus WM therapy group,significantly higher than 19.2％ (43/224) in the WM therapy group (P＜0.01).No drug-related adverse events were observed during the course of the study.Conclusions:The combined CM and WM therapy achieved a better therapeutic efficacy in treating severe HFMD than the WM therapy alone.Reduning or Xiyanping Injections may become an important complementary therapy to WM for relieving the symptoms of severe HFMD.