Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2017,（5）
• 页码范围: 576-584
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s12264-017-0164-8

摘要

Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism,and it may serve as a prodromal marker of neurodegenerative disease.The mechanism underlying RBD is unclear.Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease,including olfactory dysfunction,abnormal color vision,autonomic dysfunction,excessive daytime sleepiness,depression,and cognitive impairment.Parkinson's disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD.In this review,we describe the main clinical and pathogenic features of RBD,focusing on its association with other non-motor symptoms of parkinsonism.