Protective Effects of Traditional Tibetan Medicine Zuo-Mu-A Decoction(佐木阿汤) on the Blood Parameters and Myocardium of High Altitude Polycythemia Model Rats

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2017,（12）
• 页码范围: 908-915
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s11655-016-2500-7

摘要

Objective:To explore the protective effects of Tibetan medicine Zuo-Mu-A Decoction（佐木阿汤,ZMAD) on the blood parameters and myocardium of high altitude polycythemia (HAPC) model rats.Methods:Forty male Wistar rats were randomly divided into 4 groups by a random number table,including the normal,model,Rhodiola rosea L.(RRL) and ZMAD groups (10 in each group).Every group was raised in Lhasa to create a HAPC model except the normal group.After modeling,rats in the RRL and the ZMAD groups were administered intragastrically with RRL (20 mL/kg) and ZMAD (7.5 mL/kg) once a day for 2 months,respectively;for the normal and the model groups,5 mL of distilled water was administered intragastrically instead of decoction.Then routine blood and hematologic rheology parameters were taken,levels of erythropoietin and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were tested,and ultrastructural change in the left ventricular myocardium was observed using transmission electron microscopy.Results:Compared with the model group,ZMAD significantly reduced the red blood cell count,hemoglobin levels,whole blood viscosity at low/middle shear rates,plasma viscosity,erythrocyte electrophoretic time,erythropoietin and 8-OHdG levels,and also increased the erythrocyte deformation index (P＜0.05).There was no difference in all results between the RRL and the ZMAD groups.The cardiac muscle fibers were well-protected,mitochondrial matrix swelled mildly and ultrastructure changes were less prominent in the ZMAD group compared with the model group.Conclusion:ZMAD has significant protective effects on the blood parameters against HAPC,and also has the beneficial effect in protecting against myocardial injury.