Identification of Inference Genes in Breast Cancer Network

• 作者: Keilash Chirom Md. Zubbair Malik R. K. Brojen Singh Romana Ishrat Shahnawaz Ali
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Breast Cancer NETWORK Theory INFERENCE Genes TOPOLOGICAL Propreties CENTRALITY
• 年，卷（期）: 2017,（9）
• 页码范围: 29-42
• 页数: 14页
• 分类号: R73

摘要

Complex breast cancer network constructed from experimentally verified seventy genes, by coordinating standard seven human protein and genome databases, follows hierarchical scale free features. Centrality based method of identification of inferred genes is implemented to this network and has predicted forty nine breast cancer genes, and nineteen non-breast cancer genes. As predicting good candidate genes before experimental analysis will save time and effort both. Fourteen genes out of nineteen are found to involve in various types of cancer and diseases, and five genes are engaged in non-cancer diseases. Some of the inferred genes need proper experimental investigation to understand fundamental roles of these genes in regulating breast cancer network.