Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei

• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2017,（9）
• 页码范围: 680-683
• 页数: 4页
• 分类号: R284.1
• 语种: 英文
• DOI: 10.3724/SP.J.1009.2017.00680

摘要

Two new phragmalin-type limonoids orthoesters,encandollens A and B (1 and 2),were isolated from the stem barks of Entandrophragma candollei collected in Ghana.The structures of these compounds were elucidated on the basis of HR-ESI-MS,1H and 13C NMR,HSQC,HMBC,and ROESY data.Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester.Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells.