High glucose stimulates proliferation and inhibits apoptosis of non-small-cell lung cancer cells by JNK-mediated downregulation of p53 pathway

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（3）
• 页码范围: 286-288
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmw137

摘要

Accumulating epidemiological studies suggest that diabetes mellitus (DM) may play a critical role in facilitating the progression and metastasis of some tumors such as colorectal,pancreas,and breast cancer [1].In aspect of non-small-cell lung cancer (NSCLC),despite the uncertainty in the prognostic significance of preexisting DM for it,increasing data have suggested the negative prognostic value of hyperglycemia for the survival of NSCLC patients [2-4].