Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics

• 来源期刊: 中国科学（化学）
• 年，卷（期）: 2017,（9）
• 页码范围: 1219-1229
• 页数: 11页
• 语种: 中文
• DOI: 10.1007/s11426-017-9088-x

摘要

Gold nanoparticles (AuNPs) have been attractive for nanomedicine because of their pronounced optical properties.Here,we customerized the methods to synthesize two types of gold nanostars,Au nanostars-1 and Au nanostars-2,which have different spire lengths and optical properties,and also spherical AuNPs.Compared to nanospheres,gold nanostars were less toxic to a variety of cells,including macrophages.Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that ofnanospheres,and but reveled less liver retention than nanospheres.Due to their strong absorption in the near-infrared (NIR),Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm,and elicited a robust photothermal therapy (PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells.Meanwhile,Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy (SERS) in 4T 1 cells.Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy.