A Fiber Tractography Study of Social-Emotional Related Fiber Tracts in Children and Adolescents with Autism Spectrum Disorder

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2017,（6）
• 页码范围: 722-730
• 页数: 9页
• 语种: 英文

摘要

The symptoms of autism spectrum disorder (ASD) have been hypothesized to be caused by changes in brain connectivity.From the clinical perspective,the "disconnectivity" hypothesis has been used to explain characteristic impairments in "socio-emotional" function.Therefore,in this study we compared the facial emotional recognition (FER) feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD (HFA) and their typically developing (TD) counterparts.The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders.Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group (P ＜ 0.01).In conclusion,the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.