Generation and characterization of monoclonal antibodies against the NS1 protein of H17N10 bat influenza virus

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（7）
• 页码范围: 649-651
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmx044

摘要

H17N10 subtype Influenza A virus (IAV) in the little yellowshouldered bat and H18N11 subtype IAV in the flat-faced fruit-eating bat are evolutionarily distinct from all other circulating IAVs [1,2].Three H17N10 genomes (A/little yellow-shouldered bat/ Guatemala/164/2009,A/little yellow-shouldered bat/Guatemala/153/2009,A/little yellow-shouldered bat/Guatemala/060/2010) and one H18N11 genome (A/flat-faced bat/Peru/033/2010) have been identified and reconstructed by reverse transcription-polymerase chain reaction (RT-PCR) analysis;however,no live virus has been isolated [1,2].The genome of bat influenza virus (BIV) maintains the same architecture and coding potential as IAVs.H17N10 viral RNAs were initially detected through bat rectal swabs and subsequently in liver,kidney,intestine,and lung tissues [1].H18N1 t viral RNAs were also first detected through bat rectal swabs,and then exclusively in intestinal tissue [2].Thus far,infectious BIVs have not been recovered from bats,but the abundance of genomic RNAs in the intestine suggests that the tissue tropism of BIV is akin to that of IAVs,as IAVs replicate mainly in the intestinal tract of aquatic birds [3,4].