Regucalcin plays a role in the cytoskeleton regulation of HepG2 cells

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（2）
• 页码范围: 193-195
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmw122

摘要

Regucalcin (RGN),also known as senescence maker protein-30,is a unique calcium-binding protein which lacks of classic EF-hand motif [1].It is mainly expressed in the liver and kidney and highly conserved in the coding region among eukaryotes [2].RGN is involved in regulating a series of cellular processes,such as intracellular calcium homeostasis,calcium signal transduction,cell metabolism,function of the nuclei,and gene expression [3-5].Given that calcium exerts a profound effect on cytoskeleton,and cytoskeleton alteration is closely related to tumor formation,invasion,and metastasis [6],we speculated that RGN might play a role in cytoskeleton rearrangement and further affect cytoskeleton associated signaling pathways.