Alteration of SSAO interactome reveals weakened cell adhesion and motor function of adipocytes in T2D

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（9）
• 页码范围: 845-847
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmx069

摘要

Semicarbazide-sensitive amine oxidases (SSAO)/VAP-1/AOC3 functions as an adhesion protein to mediate leukocyte migration in inflammation,which also belongs to SSAOs [1].Accumulating evidence indicated the relevance of SSAO with diabetes mellitus.It has been reported that SSAO substrates have therapeutic effect on insulin-resistant diabetes [2].SSAO might be a promising drug target to control diabetes complications.Thus,an in-depth study of SSAO interactome is needed for a better understanding of its biological functions in diabetes.