Natural killer cells are activated and play a protective role against ZIKA virus infection in mice

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2017,（14）
• 页码范围: 982-984
• 页数: 3页
• 语种: 英文

摘要

Zika virus (ZIKV) is a mosquito-borne Flavivirus that was responsible for an epidemic in the Americas during 2015-2016 [1].ZIKV infections in adults have been linked to Guillain-Barré syndrome [2,3],as well as abnormalities such as abortion,stillbirth,and microcephaly in some cases [4].In addition,we have reported that ZIKV infect testicular stem-like peritubular myoid cells (TPC) and spermatogonia (SG),and induce inflammation in the testis and epididymidis [5].Immunocompromised mice models have been primarily used to characterize the pathogenesis of ZIKV infection in previous studies.The immune responses to ZIKV infection in immunocompetent host remain poorly understood.