Sas/PTP10D signaling drives tumor-suppressive cell competition

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: @@
• 年，卷（期）: 2017,（9）
• 页码范围: 851-852
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/abbs/gmx070

摘要

Cell competition possesses a cell fitness-sensing process ranging from Drosophila to mammals that selectively eliminates aberrant cells via apoptosis.The presence of cell competitive interaction will determine whether the cell contributes to the survival of organisms.Yamamoto et al.[1] recently reveal a hitherto unexplored mechanism by which the surrounding normal epithelial cells can recognize oncogenic polarity-deficient neighbors to trigger tumor-suppressive cell competition in Drosophila.