PhI(OAc)2-promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2017,（6）
• 页码范围: 761-768
• 页数: 8页
• 语种: 英文
• DOI: 10.1007/s11426-016-0478-3

摘要

Umpolung is a fundamental concept in organic chemistry,which provides an alternative strategy for the synthesis of target compounds which were not easily accessible by conventional methods.Herein,a mild and efficient PhI(OAc)2-promoted umpolung acetoxylation reactions of enamides was developed for the synthesis of α-acetoxy ketones.The reaction tolerates a wide range of functional groups and affords α-acetoxy ketones in good to excellent yields.PhI(OAc)2 serves as a source of acetoxy in the reaction.