Copper-catalyzed enantioselective cyanation of benzylic C-H bonds via radical relay

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2017,（1）
• 页码范围: 105-106
• 页数: 2页
• 语种: 中文
• DOI: 10.1007/s11426-016-0441-6

摘要

Direct methods that enable stereoselective functionalization of C(sp3)-H bonds could facilitate efficient preparation of therapeutics and agrochemicals,and shall have a major effect on the discovery and development of new pharmaceuticals.Although the transformations through C(sp2)-H bond cleavage have been significantly developed in the past decades,the direct C(sp3)-H functionalization,especially the asymmetric transformation is still a big challenge.