Biocormpatibility and biotoxicity of in-situ synthesized carboxylated nanodiarnond-cobalt oxide nanocomposite

• 来源期刊: 材料科学技术（英文版）
• 年，卷（期）: 2017,（8）
• 页码范围: 879-888
• 页数: 10页
• 语种: 英文

摘要

A nanocomposite that incorporates cobalt oxide (Co3O4) and nanodiamond (ND) can present both high magnetism (Co3O4) and high hardness (ND).ND particles have potential applications in a variety of fields such as protein immobilization,biosensors,therapeutic molecule delivery and bio-imaging.However,limited information is available in literature on the in-situ synthesis of biocompatible magnetic materials and also on their potential biotoxicity as a result of their entry into environmental compartments and subsequent interaction with biota.In this work,a new kind of bio-compatible magnetic material carboxylated nanodiamond (cND) and Co3O4 was synthesized to obtain the cND-Co3O4 nanocomposite.The synthesis procedure involved in-situ and chemical reduction of cobalt chloride (CoCl2 6H2O) and sodium borohydrate (NaBH4).The synthesized cND-Co3O4 nanocomposite was characterized by X-ray diffraction,scanning electron microscopy,transmission electron microscopy and X-ray photoelectron spectroscopy.The cyto-genotoxicity of the synthesized nanocomposite material was studied by using onion (Allium cepa L.) as a test model with concentrations of 5,10 and 20 μg/ml.The study was also extended to cND and Co3O4 materials for comparison purpose.Co3O4 and cND exhibited their contrasting effects on mitosis and other cyto-genotoxic indices studied herein.This work provided fundamental data on the synthesis and the bio-toxicity of the cND-Co3O4 nanocomposite,which,in turn,can help to expand their multidisciplinary applications.