Intraocular pressure control of a novel glaucoma drainage device-in vitro and in vivo studies

• 作者: Di-Chen Li Jian Liu Lei Zhang Li-Jun Cui Yao Xing
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 年，卷（期）: 2017,（9）
• 页码范围: 1354-1360
• 页数: 7页
• 分类号: R77

摘要

AIM: To evaluate the intraocular pressure(IOP) control of an artificial trabeculum drainage system(ATDS), a newly designed glaucoma drainage device, and postoperative complications in normal rabbit eyes. METHODS: Pressure drops in air and fluid of 30 ATDS were measured after being connected to a closed manometric system. Twenty of them were then chosen and implanted randomly into the eyes of 20 rabbits. Postoperative slitlamp, gonioscopic examination and IOP measurements were recorded periodically. Ultrasound biomicroscopy and B-scan ultrasonography were also used to observe the complications. Eyes were enucleated on day 60. RESULTS: Pressure drops of 4.6-9.4 mm Hg were obtained at physiological aqueous flow rates in the tests in vitro. The average postoperative IOP of the experimental eyes(11.6-12.8 mm Hg) was lower than the controls significantly(P<0.05) at each time point. Complications of hemorrhage(n=1), cellulosic exudation(two cases) and local iris congestion(two cases) were observed. The lumina of the devices were devoid of obstructions in all specimens examined and a thin fibrous capsule was found around the endplate. CONCLUSION: ATDS reduce IOP effectively. However, further studies on the structure are needed to reduce complications.