The main purpose of the present work is to discuss whether or not the collective flows in heavy-ion collision at the Fermi energy can be taken as a tool to investigate the cluster configuration in light nuclei.In practice,within an extended quantum molecular dynamics model,four α-clustering (linear chain,kite,square and tetrahedron)configurations of 16O are employed in the initialization,16 O+16O around the Fermi energy (40-60 MeV/nucleon) with impact parameter 1-3 fm are simulated,and the directed and elliptic flows are analyzed.It is found that collective flows are influenced by the different α-clustering configurations,and the directed flow of free protons is more sensitive to the initial cluster configuration than the elliptic flow.Nuclear reaction at the Fermi energy can be taken as a useful way to study cluster configuration in light nuclei.