2型固有淋巴细胞和miR-155在变应性鼻炎中的研究现状

• 作者: 刘月辉 朱亚琼
• 来源期刊: 临床耳鼻咽喉头颈外科杂志
• 学科: 医学
• 关键词: 鼻炎,变应性 2型固有淋巴细胞 miR-155
• 年，卷（期）: 2017,（24）
• 所属期刊栏目: 综述
• 页码范围: 1940-1943
• 页数: 4页
• 分类号: R765.21
• 语种: 中文
• DOI: 10.13201/j.issn.1001-1781.2017.24.019

摘要

Allergic rhinitis (AR) is the Th2 inflammatory response that atopic individuals exposure to allergens,mediators released by IgE-mediated,and a variety of immunocompetent cells and cytokines involved.Group 2 innate lymphoid cells (ILC2) are a novel population of native lymphocyte,can secrete large amounts of Th2 cytokines to promote the development of allergic diseases after being activated.MiR-155 plays a vital role in the development of the immune system,the differentiation of immune cells,and the maintenance of immune function.Nasal mucosas from the patients with allergic rhinitis show enrichment for ILC2 and miR-155.Highly expressed miR-155 may enhance the level of IL-4 by promoting ILC2 expression,thereby promoting Th2 inflammatory response.This review focuses on the function and meaning of ILC2 and miR-155 in patients with Allergic rhinitis.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	朱亚琼		1	0	0.0	0.0
2	刘月辉		1	0	0.0	0.0