Hepatoprotective Effect of Green Tea Extract against Cyclophosphamide Induced Liver Injury in Albino Rats

• 作者: Ali Hassan A. Ali
• 来源期刊: 法医学与解剖学研究(英文)
• 学科: 医学
• 关键词: Green TEA ALBINO Rats Liver CYCLOPHOSPHAMIDE
• 年，卷（期）: 2018,（2）
• 页码范围: 11-19
• 页数: 9页
• 分类号: R73

摘要

Background: Green tea intake is accompanied with a lower incidence of cardiovascular disease, cancer and neurodegenerative disorders;hence green tea extract has been included as dietary supplement along with other supplements and multivitamins. Aim of the Work: Studying the effect of cyclophosphamide administration on the liver of adult male albino rats and the possible protective role of green tea extract. Material and Methods: The current study was carried out on 45 adult male albino rats. They were divided into three equal groups (each included 15 rats). Group I (control group) was injected intraperitoneally with normal saline at a dosage of 0.5 mg/kg body weight twice weekly for 9 weeks. Group II was injected intraperitoneally with cyclophosphamide (CP) (150 mg/kg/day) for two weeks. Group III: rats received green tea extracts orally (50 mg/kg/day) for three weeks, and then continued for further two weeks concomitantly with intraperitoneally cyclophosphamide (CP) injected (150 mg/kg/day). Results: Rats exposed to cyclophosphamide (CP) showed several histological and histochemical changes in their liver. These changes were improved by using green tea. Conclusion: The present work showed that green tea had preventive and therapeutic effect upon livers of albino rats after they were exposed to CP.