Detailed structure and regulation of ATR kinase

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2018,（2）
• 页码范围: 6
• 页数: 1页
• 语种: 英文

摘要

With the support by the National Natural Science Foundation of China,the research team directed by Prof.Cai Gang(蔡刚)at the Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences,University of Science and Technology of China,becomes the first to determine the structure of the ATR-ATRIP complex in near-atomic detail,which reveals the regulatory mechanism of ATR activity and may shed lights on future cancer therapy.Related study was published in Science (2017,358:1206-1209).