Ruthenium (Ⅱ)-catalyzed synthesis of phthalides via the cascade addition and cyclization of aromatic acids with aldehydes

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（2）
• 页码范围: 153-158
• 页数: 6页
• 语种: 英文

摘要

The ruthenium-catalyzed intermolecular cascade cyclization of aromatic acids with aromatic aldehydes,which involves the direct insertion of C-H bond into a polar C=O bond and the successive intramolecular nucleophilic substitution,was developed for the synthesis of 3-substituted phthalides in good to excellent yields.This one-pot procedure characterizes in a short reaction time,the cheaper Ru(Ⅱ) as a catalyst,readily available acids and aldehydes as starting materials,and water as the only theoretical by-product.These merits make the protocol an efficient and cost-effective route for the synthesis of 3-substituted phthalides.