Circulating microRNAs as biomarkers for diabetic neuropathy:A novel approach

• 作者: Andreas Melidonis Athanasia Papazafiropoulou Eleni Xourgia
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: DIABETIC NEUROPATHY TYPE 2 DIABETES MELLITUS TYPE 1 DIABETES MELLITUS EPIGENETIC MicroRNAs
• 年，卷（期）: 2018,（3）
• 页码范围: 18-23
• 页数: 6页
• 分类号: R

摘要

Oxidative stress stemming from tissue exposure to constant hyperglycemia is one of the major pathogenetic pathways of diabetic macro-and microvascular complications.Diabetic polyneuropathy,commonly manifesting as distal,symmetrical sensorimotor polyneuropathy,is characterized by progressive severity of symptoms,with rates analogous to the quality of glycemic control achieved by the patients and physicians.Palliative care with analgesics and aggressive glycemic control often improve quality of life in the absence of causative treatment.Currently,there is a growing body of evidence indicating the role of microRNAs in the pathogenesis of diabetic complications,with emphasis on diabetic nephropathy and neuropathy.Therefore,in this review,we aim to explore the role of microRNAs and their polymorphisms in the pathophysiology of diabetic polyneuropathy,as well as,the possibility of novel diagnostic and therapeutic applications by epigenetic profiling and manipulation.