Partner switching for Ran during the mitosis dance

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2018,（1）
• 页码范围: 89-90
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/jmcb/mjx048

摘要

Mitosis is one of the most fascinating processes in biology,and is often described as a well-choreographed dance.During mitosis,sister chromatids attach to dynamic microtubules in the mitotic spindle,align and oscillate at the metaphase plate,separate synchronously at the metaphase-anaphase transition,and are partitioned equally into the two daughter cells.Chromosome missegregation leads to aneuploidy and genomic instability,which can drive tumorigenesis under certain contexts.Combining structural biology,biochemistry,and cell biology methods,Bao et al.(2017) show that the acetylation of the small GTPase Ran switches its preference for binding partners,and acts as an important molecular switch for proper chromosome alignment and mitotic progression in human cells (Figure 1).