Oxygen as an oxidant in rhodium(Ⅲ) catalyzed oxidative C-H/C-H cross-coupling between indoles and oxazoles

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（2）
• 页码范围: 200-205
• 页数: 6页
• 语种: 英文

摘要

A Rh(Ⅲ)-catalyzed oxidative C-H/C-H cross-coupling between indoles and oxazoles with molecular oxygen as an oxidant has been developed to construct a variety of 2-(indol-2-yl)oxazoles.The chelation-assisted strategy endows this catalytic system with an excellent C2-site selectivity by introducing a pyrimidyl directing group.In addition,polycyclic pyridinium salts are also obtained via Rh(Ⅲ)-catalyzed C-H activation/cyclization of 2-(indol-2-yl)oxazoles with alkynes.