A loss-of-function mutation in LIMA1 decreases intestinal cholesterol absorption and prevents cardiovascular disease

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2018,（3）
• 页码范围: 4
• 页数: 1页
• 语种: 英文

摘要

Supported by the National Natural Science Foundation of China,a collaborative study by the laboratories of Dr.Song BaoLiang(宋保亮)from Wuhan University and Dr.Ma YiTong(马依彤)from the First Affiliated Hospital of Xinjiang Medical University demonstrates that a rare frameshift mutation in the LIMA1 gene promotes low plasma low-density lipoprotein cholesterol (LDL-C) and decreases intestinal cholesterol absorption.This work was recently published in Science (2018,360(6393):1087-1092).