Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

• 来源期刊: 药学学报（英文版）
• 关键词: Cell membrane Biomimetic nanoparticle Drug delivery Cancer targeting Circulation Molecular recognition
• 年，卷（期）: 2018,（1）
• 页码范围: 14-22
• 页数: 9页
• 语种: 英文

摘要

Taking inspiration from nature,the biomimetic concept has been integrated into drug delivery systems in cancer therapy.Disguised with cell membranes,the nanoparticles can acquire various functions of natural cells.The cell membrane-coating technology has pushed the limits of common nano-systems (fast elimination in circulation) to more effectively navigate within the body.Moreover,because of the various functional molecules on the surface,cell membrane-based nanoparticles (CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor.Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy.In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field.