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摘要:
We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese version of the Support Team Assessment Schedule. The psoas muscle index (PMI) was used to define sarcopenia. A statistically significant difference was observed in the PMI between patients receiving low-dose (3.6 ± 1.2 cm2/m2) and high-dose furosemide (3.1 ± 1.2 cm2/m2) before tolvaptan treatment (P = 0.048). The PMI increased from 3.2 ± 1.1 cm2/m2 to 3.5 ± 1.3 cm2/m2 (P = 0.002) in responders, but decreased from 3.4 ± 1.2 cm2/m2 to 3.0 ± 1.0 cm2/m2 (P = 0.106) in non-responders before and after tolvaptan treatment, respectively. The long-term prognosis improved in responders compared with non-responders (mean survival time: 646 days vs. 228 days, P < 0.001). Early introduction of tolvaptan treatment is necessary to prevent the progression of sarcopenia.
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篇名 The Effect of Loop Diuretics on Sarcopenia and Long-Term Prognosis in Patients with Refractory Hepatic Ascites Treated with Tolvaptan
来源期刊 肠胃病学期刊(英文) 学科 医学
关键词 TOLVAPTAN HEPATIC ASCITES SARCOPENIA Loop DIURETICS Long-Term Prognosis
年,卷(期) 2018,(6) 所属期刊栏目
研究方向 页码范围 201-208
页数 8页 分类号 R5
字数 语种
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研究主题发展历程
节点文献
TOLVAPTAN
HEPATIC
ASCITES
SARCOPENIA
Loop
DIURETICS
Long-Term
Prognosis
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
肠胃病学期刊(英文)
月刊
2163-9450
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
108
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0
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0
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