Roles of H3K36-specific histone methyltransferases in transcription: antagonizing silencing and safeguarding transcription fidelity

• 来源期刊: 生物物理学报
• 年，卷（期）: 2018,（4）
• 页码范围: 170-177
• 页数: 8页
• 语种: 中文

摘要

Histone H3K36 methylation is well-known for its role in active transcription.In Saccharomyces cerevisiae,H3K36 methylation is mediated solely by SET2 during transcription elongation.In metazoans,multiple H3K36-specific methyltransferases exist and contribute to distinct biochemical activities and subsequent functions.In this review,we focus on the H3K36-specific histone methyltransferases in metazoans,and discuss their enzymatic activity regulation and their roles in antagonizing Polycomb silencing and safeguarding transcription fidelity.