Influence of Distinct Radiotherapy Techniques to Induce Second Cancer Risks in Left Breast Cancer

• 作者: Ehab M. Attalla Mostafa A. Elnaggar Raghda A. Elgendy Wahib M. Attia
• 来源期刊: 医学物理学、临床工程、放射肿瘤学(英文)
• 学科: 医学
• 关键词: Breast CANCER Second CANCER RISKS 3DCRT 7 Field IMRT
• 年，卷（期）: 2018,（2）
• 页码范围: 193-202
• 页数: 10页
• 分类号: R73

摘要

Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two tangential beams 3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk from Organ equivalent dose models (OEDs) in three dose-response model for organs at risk in left breast cases. Results: The P-value for OED models in 3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid, liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E-06, 5.79E-07, 0.003, 1.78E-10 and 0.000206475 respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E-06, 3.28E-07, 0.003, 2.01E-10 and 0.000120072 respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E-06, 2.53E-07, 0.003, 2.27E-10 and 9.00535E-05 respectively. Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams.