Chemical Composition, Anticancer, Anti-neuroinflammatory, and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2018,（3）
• 页码范围: 207-212
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11655-016-2459-4

摘要

Objective:To study the chemical composition,anticancer,anti-neuroinflammatory,and antioxidant activities of the essential oil of Patrinia scabiosaefolia (EO-PS).Methods:Patrinia scabiosaefolia was analyzed by gas chromatography-mass spectrometry.Eight human carcinoma cell lines,including SGC-7901,AGS,HepG2,HT-29,HCT-8,5-FU/HCT-8,HeLa,and MDA-MB-231,were assessed by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay.Anti-neuroinflammatory activity was assessed by production of interleukin (IL)-1 β and IL-6 induced by lipopolysaccharide in BV-2 cells (microglia from mice).The antioxidant activity was evaluated with a 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay.Results:Forty-four components,representing 83.919％ of the total oil,were identified in the EO-PS.The major constituents were caryophyllene oxide (12.802％),caryophyllene (6.909％),α-caryophyllene (2.927％),β-damascenone (3.435％),calarene (5.621％),and phenol (3.044％).The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50-200 μ g/mL dilution range.The EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical,with an half of maximal inhibitory concentration 1.455 mg/mL.Conclusion:The EO-PS possesses a wide range of antitumor,anti-neuroinflammatory and antioxidant activities,suggesting that it may be a good candidate for further investigations of new bioactive substances.