A single biomolecule interface for advancing the sensitivity, selectivity and accuracy of sensors

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2018,（4）
• 页码范围: 450-452
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/nsr/nwy029

摘要

The performance of a sensor is mainly determined by its interface with sensing molecules,which comprises reactive molecules for the recognition,active molecules for the signal responses and/or functional materials for signal enhancement (Fig.la(i)).For example,a double layer is set up at the electrode/electrolyte interface,across which charge-transfer reactions occur.In a previous study [1],a membrane interface was constructed onto the electrode,in which ubiquinone was embedded in a hybrid bilayer membrane,facilitating the charge/electron transfer from the NADH (nicotinamide-adenine dinudeotide) to the electrode.This interface mimics the initial stages of respiration to achieve the reversible interconversion between NADH and NAD+ at a low overpotential.Therefore,a local chemical environment is established at the sensor interface,where the electrode potential is measured,giving the information about the analyte.Using the macroscalesensing interface,traditional sensors have been applied in the wide range of detection.