Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（1）
• 页码范围: 74-84
• 页数: 11页
• 语种: 英文

摘要

To investigate the behavioral and biomolecular similarity between neuralgia and depression,a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain.A mouse learned helplessness (LH) model was developed to investigate inescapable footshock-induced psychiatric disorders like depression in humans.Mass spectrometry was used to assess changes in the biomolecules and signaling pathways in the hippocampus from TN or LH mice.TN mice developed not only significant mechanical allodynia but also depressivelike behaviors (mainly behavioral despair) at 2 weeks after CION,similar to LH mice.MS analysis demonstrated common and distinctive protein changes in the hippocampus between groups.Many protein function families (such as cell-to-cell signaling and interaction,and cell assembly and organization,) and signaling pathways (e.g.,the Huntington's disease pathway) were involved in chronic neuralgia and depression.Together,these results demonstrated that the LH and TN models both develop depressive-like behaviors,and revealed the involvement of many psychiatric disorder-related biomolecules/pathways in the pathogenesis of TN and LH.