Deep pedigree analysis reveals family specific "fingerprint" pattern of DNA methylation for men

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2018,（1）
• 页码范围: 7-10
• 页数: 4页
• 语种: 英文

摘要

DNA methylation plays an essential role in mammalian development [1].However,how DNA methylation is inherited between generations and if there is family-specific DNA methylation pattern remains to be elucidated [2].In this study,we collect male blood samples including a big pedigree of the descendants of an ancient Chinese empire and samples from different haplogroups to study their whole genome DNA methylation pattern.We find 115 male family-specific methylation sites from three families.The difference of whole genome DNA methylation pattern correlates with the remote divergence time between samples.Overall,we showed a high correlation between the DNA methylation profile and the blood relationship within male family members,but not female family members.