Peripheral Leptin Signaling Mediates Formalin-Induced Nociception

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（2）
• 页码范围: 321-329
• 页数: 9页
• 语种: 英文

摘要

Accumulating evidence suggests that obesity is associated with chronic pain.However,whether obesity is associated with acute inflammatory pain is unknown.Using a well-established obese mouse model induced by a highfat diet,we found that:(1) the acute thermal pain sensory threshold did not change in obese mice;(2) the model obese mice had fewer nociceptive responses in formalininduced inflammatory pain tests;restoring the obese mice to a chow diet for three weeks partly recovered their pain sensation;(3) leptin injection induced significant phosphorylation of STAT3 in control mice but not in obese mice,indicating the dysmodulation of topical leptin-leptin receptor signaling in these mice;and (4) leptin-leptin receptor signaling-deficient mice (ob/ob and db/db) or leptin-leptin receptor pathway blockade with a leptin receptor antagonist and the JAK2 inhibitor AG 490 in wildtype mice reduced their nociceptive responses in formalin tests.These results indicate that leptin plays a role in nociception induced by acute inflammation and that interference in the leptin-leptin receptor pathway could be a peripheral target against acute inflammatory pain.