Single-molecule devices reveal step-by-step dynamics of hydrogen bonds

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（6）
• 页码范围: 639-640
• 页数: 2页
• 语种: 英文

摘要

Intermolecular interactions, including hydrogen bonding, hydrophobic interactions, halogen bonding etc., are ubiquitous in nature, which play key roles in the basic chemical, physical and biochemical process of life.Among them, hydrogen bonds are particularly attractive because they dominate many important structures and functions in nature from elegant base-pair interactions in DNAs to sophisticated protein folding and are regarded as an important element in the discovery of new pharmaceuticals.To better elucidate fundamental mechanisms, many studies have been carried out by using conventional spectroscopic methods where the signals stem from the ensemble experiments and the hydrogen-bond dynamics were deduced indirectly.Direct observation of the dynamic process of hydrogen bonds at the single-molecule level, is important, however more difficult.