Current Status of Neuromodulatory Therapies for Disorders of Consciousness

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（4）
• 页码范围: 615-625
• 页数: 11页
• 语种: 英文

摘要

Treatment for disorders of consciousness (DOCs) is still a Gordian knot.Evidence-based guidelines on the treatment of DOC patients are not currently available,while neuromodulation techniques are seen as a potential treatment.Multiple neuromodulation therapies have been applied.This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients.Both invasive and non-invasive brain stimulation is discussed.Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare.The efficacy of various such therapies remains a matter of debate.Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed,and new approaches are awaited.