KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China

• 来源期刊: 中国病毒学
• 年，卷（期）: 2018,（4）
• 页码范围: 369-372
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, Natural killer (NK) cells are lymphocytes that play important roles in the host defense against hepatitis C virus (HCV) infection.Killer cell immunoglobulin-like receptors (KIRs) are a group of regulatory molecules expressed on NK cells and a subset of T cells (Parham 2005).Ligands for KIRs are human leukocyte antigen (HLA) class Ⅰ molecules,and HLA-C1 is a ligand for the inhibitory receptors KIR2DL2,KIR2DL3 and the activating receptor KIR2DS2 (Robinson et al.2003;Du et al.2007).