Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2018,（4）
• 页码范围: 324-329
• 页数: 6页
• 语种: 英文
• DOI: 10.4103/aja.aja_81_17

摘要

This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population.A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study.The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively.Among 2133 patients included in the analysis,947 (44.4％) were diagnosed with PCa.The mean age,PSA,and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P ＜ 0.05).The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851,respectively,in predicting PCa in the entire population,both performed better than PSA (AUC =0.805;P ＜ 0.05).The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml-1 to 20.0 ng ml-1.A PSA-AV score of 400 had a sensitivity and specificity of 93.7％ and 40.0％,respectively.In conclusion,the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa.This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population.