Functions and the related signaling pathways of the neurotrophic factor neuritin

• 来源期刊: 中国药理学报（英文版）
• 关键词: neuritin neurotrophic factor insulin receptor MEK-ERK pathway PI3K-Akt-mTOR pathway Ca2+-CaN-NFATc4 pathway
• 年，卷（期）: 2018,（9）
• 页码范围: 1414-1420
• 页数: 7页
• 语种: 英文
• DOI: 10.1038/aps.2017.197

摘要

Neuritin is a member of the neurotrophic factor family, which is activated by neural activity and neurotrophins, and promotes neurite growth and branching. It has shown to play an important role in neuronal plasticity and regeneration. It is also involved in other biological processes such as angiogenesis,tumorigenesis and immunomodulation. Thus far, however, the primary mechanisms of neuritin, including whether or not it acts through a receptor or which downstream signals might be activated following binding, are not fully understood. Recent evidence suggests that neuritin may be a potential therapeutic target in several neurodegenerative diseases. This review focuses on the recent advances in studies regarding the newly identified functions of neuritin and the signaling pathways related to these functions. We also discuss current hot topics and difficulties in neuritin research.