Haplotype Frequency Comparison for Case-Parents Data

• 作者: Caixia Li Peixing Li
• 来源期刊: 统计学期刊(英文)
• 学科: 医学
• 关键词: HAPLOTYPE Transmission Disequilibrium TEST LIKELIHOOD RATIO TEST EXPECTATION-MAXIMIZATION Algorithm
• 年，卷（期）: tjxqkyw_2018,（4）
• 页码范围: 721-730
• 页数: 10页
• 分类号: R73

摘要

For case-parents data, the information from offspring can be used to reduce the uncertainty of parents’ haplotype. In this article we develop likelihood ratio test to compare haplotype frequencies in transmitted and non-transmitted group. The maximum likelihood estimate of the haplotype frequencies for the family data is obtained via expectation-maximization (EM) algorithm. Our proposed method can handle the uncertainty of haplotypes and missing data. The simulations show that the method is more powerful to test association between haplotype and traits than TRANSMIT. We also demonstrated the method to detect the association between Megsin gene and immunoglobulin A nephropathy.