Structure insight of GSDMD reveals the autoinhibition basis in cell pyroptosis

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2018,（2）
• 页码范围: 25
• 页数: 1页
• 语种: 英文

摘要

With the support by the National Natural Science Foundation of China,a research group led by Prof.Li JiXi (李继喜) from Fudan University demonstrates that the C-terminal of gasdermin D (GSDMD-C) acts as an autoinhibition executor and its N-terminal domain could form pore structures via a charge-charge interaction upon cleavage by caspases during cell pyroptosis,which was published in PNAS (2017,114(40):10642-10647).