Biothiol-specific fluorescent probes with aggregation-induced emission characteristics

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（8）
• 页码范围: 882-891
• 页数: 10页
• 语种: 英文

摘要

signalling. Alternation in the biothiol levels is associated with various pathological processes, therefore non-invasive fluorescent probes with high specificity to biothiols are highly desirable research utilities. Meanwhile, fluorescent probes with aggregationinduced emission properties (AIEgens) possess unique photophysical properties that allow modulation of the sensing process through controlling the aggregation-disaggregation or the intramolecular rotational motions of the fluorophores. Herein we review the recent progress in the development of biothiol-specific AIEgens. In particular, the molecular design principles to target different types of biothiols and the corresponding sensing mechanisms are discussed, along with the potential of the future design and development of multi-functional bioprobes.