Recent developments in peptide ligation independent of amino acid side-chain functional group

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（1）
• 页码范围: 97-112
• 页数: 16页
• 语种: 英文
• DOI: 10.1007/s11426-017-9056-5

摘要

Chemical synthesis of peptides and proteins has evolved into an indispensable tool for chemical biology.Peptide ligation is a straightforward technique for joining two short peptide fragments together via a native peptide bond to afford a larger natural peptide or protein.However,the junction sites are limited to several specific amino acids because most peptide ligations involve participation of the side-chain functional groups of the junction-site amino acids.To overcome such intrinsic limitations,"general" peptide ligations which do not rely on the side-chain functional group have been developed.This review summarized the recent developments in peptide ligations that are independent of side-chain functional group of ligation-junction-site amino acid.