Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（1）
• 页码范围: 113-117
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11426-017-9034-y

摘要

Increasing multidrug-resistant (MDR) superbugs emerge worldwide causing a public health crisis.Consequently,it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity.By virtue of versatility in molecular design,a new peptide-like cell membrane-broken molecule,oligo-(7,7'-bifluoren-benzo[c][1,2,5]thiadiazole) (OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized.OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria,and fungi with the minimum inhibitory concentration (MIC) below 3.0 μM.Moreover,OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent.