In Vitro Angiogenesis Effect of Xuefu Zhuyu Decoction （血府逐瘀汤） and Vascular Endothelial Growth Factor: A Comparison Study

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2018,（8）
• 页码范围: 606-612
• 页数: 7页
• 语种: 英文
• DOI: 10.1007/s11655-015-2289-9

摘要

Objective:To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF)and Chinese medicine Xuefu Zhuyu Decoction(血府逐瘀汤,XZD) treatments.Methods:Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of either XZD-containing serum (XZD-CS)or VEGF for 24,48,and 72 h,respectively.Cell viability,proliferation,migration,adhesion,and in vitro tube formation assays were used to assess their angiogenic effects.Results:VEGF promoted all cellular phases involved in angiogenesis including cell viability,proliferation,migration,adhesion,and tube formation (P＜0.05 or P＜0.01).Unlike the continuous promotion effects of VEGF at the above stages,XZD inhibited cell viability and proliferation (P＜0.05 or P＜0.01) and only promoted tube formation in the early phase of angiogenesis (P＜0.01).Conclusions:These two medications promote different angiogenesis behaviors,which might be an important reason for their distinct therapeutic profile in clinical usage.